Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis
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Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis
Leishmaniases are a set of tropical and sub-tropical diseases caused by protozoan parasites of the genus Leishmania whose severity ranges from self-healing cutaneous lesions to fatal visceral infections. Leishmania parasites synthesise a wide array of cell surface and secreted glycoconjugates that play important roles in infection. These glycoconjugates are particularly abundant in the promasti...
متن کاملLeishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage?
The Leishmania parasite glycocalyx is rich in galactose-containing glycoconjugates that are synthesized by specific glycosyltransferases that use UDP-galactose as a glycosyl donor. UDP-galactose biosynthesis is thought to be predominantly a de novo process involving epimerization of the abundant nucleotide sugar UDP-glucose by the UDP-glucose 4-epimerase, although galactose salvage from the env...
متن کاملDeletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major.
The nucleotide sugar UDP-galactose (UDP-Gal) is essential for the biosynthesis of several abundant glycoconjugates forming the surface glycocalyx of the protozoan parasite Leishmania major. Current data suggest that UDP-Gal could arise de novo by epimerization of UDP-glucose (UDP-Glc) or by a salvage pathway involving phosphorylation of Gal and the action of UDP-glucose:alpha-D-galactose-1-phos...
متن کاملUDP-sugar pyrophosphorylase: a new old mechanism for sugar activation.
Abbreviations: aa, amino acid; AGPase, ADP-glc pyrophosphorylase; ara, arabinose; gal, galactose; galA, galacturonic acid; GALT, gal-1-P uridyltransferase; glc, glucose; glcA, glucuronic acid; man, mannose; PPi, pyrophosphate; SuSy, sucrose synthase; UAGPase, UDP-N-acetylglucosamine pyrophosphorylase; UGE, UDP-glc epimerase; UGPase, UDP-glc pyrophosphorylase; USPase, UDP-sugar pyrophosphorylase...
متن کاملBiosynthesis of UDP-glucuronic acid in developing soybean embryos: possible role of UDP-sugar pyrophosphorylase
doi: 10.1111/j.1399-3054.2006.00728.x During soybean [Glycine max (L.) Merrill] embryo development, cell wall polysaccharides (CWPs) derived from UDP-glucuronic acid (UDP-GlcA) (uronic acids, arabinose, xylose) exhibited a linear increase during the period of 25–45 days after flowering (daf). At embryo maturity, CWPs derived from UDP-GlcA accounted for 39% of total CWPs. To ascertain the relati...
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ژورنال
عنوان ژورنال: International Journal for Parasitology
سال: 2015
ISSN: 0020-7519
DOI: 10.1016/j.ijpara.2015.06.004